The MEK2 Rabbit Monoclonal Antibody (CAB19078) is a cutting-edge tool designed for researchers studying the MEK2 protein, a key player in the MAPK signaling pathway. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting MEK2 in human samples, making it an ideal choice for Western blot applications. By targeting the MEK2 protein, this antibody allows for accurate and reliable analysis of signaling pathways involved in cell growth, differentiation, and survival.MEK2, a crucial component of the MAPK pathway, plays a vital role in regulating cellular responses to external stimuli, such as growth factors and stress signals. Dysregulation of the MAPK pathway, including aberrant MEK2 activity, has been implicated in various diseases, including cancer and developmental disorders.
As such, understanding the function of MEK2 is essential for elucidating its role in disease pathogenesis and developing targeted therapies.The validation of this MEK2 Rabbit Monoclonal Antibody for use in research provides scientists with a valuable tool for investigating the intricate mechanisms of the MAPK pathway and its implications in disease development. With its high reactivity and specificity, this antibody offers reliable and reproducible results, enabling researchers to gain deeper insights into the role of MEK2 in cellular signaling and disease progression.
Product Name:
[KO Validated] MEK2 Rabbit Monoclonal Antibody
SKU:
CAB19078
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK2 (P36507).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
5605
Clone Number:
ARC0361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and MEK2 knockout (KO) HeLa cells, using [KO Validated] MEK2 Rabbit mAb (CAB19078) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
