The GATA2/3 Rabbit Monoclonal Antibody (CAB5083) is a powerful tool for researchers studying the GATA2 and GATA3 transcription factors, which play essential roles in developmental processes and immune system regulation. This antibody, produced in rabbits, has been rigorously validated for use in various applications, including Western blotting and immunohistochemistry.GATA2 and GATA3 are key transcription factors that regulate gene expression in hematopoietic stem cells and immune cells, influencing cell differentiation and function. Dysregulation of these factors has been linked to various diseases, including leukemia, lymphoma, and immune disorders.
By using the GATA2/3 Rabbit Monoclonal Antibody, researchers can investigate the expression levels and localization of these critical transcription factors in different cell types and tissues.With its high specificity and sensitivity, the GATA2/3 Rabbit Monoclonal Antibody provides reliable results and enables detailed analysis of GATA2 and GATA3 in both normal and diseased states. This antibody is a valuable tool for advancing our understanding of the molecular mechanisms governing immune cell development and function, with implications for the development of targeted therapies in cancer and immunological disorders.
Product Name:
[KO Validated] GATA2 Rabbit Monoclonal Antibody
SKU:
CAB5083
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human GATA2/3 (NP_116027.2).
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Purification Method:
Affinity purification
Gene ID:
2624/2625
Clone Number:
ARC1209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type (WT) and GATA2 knockout (KO) HeLa cells, using GATA2 antibody (CAB5083) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
