The KLRK1 Polyclonal Antibody (CAB6123) is a valuable tool for researchers studying the KLRK1 protein, also known as NKG2D. This cell surface receptor plays a key role in immune surveillance, specifically in the detection and elimination of stressed and infected cells. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By binding specifically to the KLRK1 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for studies in immunology, infectious diseases, and cancer research.
Understanding the role of KLRK1/NKG2D in immune responses can provide valuable insights into how the immune system identifies and targets abnormal cells, offering potential therapeutic strategies for diseases such as cancer and infections.With its ability to facilitate the study of KLRK1/NKG2D function and expression, the KLRK1 Polyclonal Antibody (CAB6123) is a valuable resource for researchers looking to unravel the complexities of immune surveillance and develop targeted therapies for immune-related diseases.
Product Name:
KLRK1 Rabbit Polyclonal Antibody
SKU:
CAB6123
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 77-216 of human KLRK1 (NP_031386.2).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
25kDa
Observed MW:
30kDa
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Purification Method:
Affinity purification
Gene ID:
22914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KLRK1 antibody (CAB6123) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
