The KLF4 Polyclonal Antibody is a powerful tool for researchers studying the role of KLF4, a transcription factor involved in cell proliferation, differentiation, and development. This antibody is produced in rabbits and is highly specific for human samples, making it ideal for use in various research applications including Western blotting.KLF4, also known as Krüppel-like factor 4, is a key regulator of gene expression and has been implicated in a wide range of biological processes, including stem cell pluripotency, cancer progression, and tissue regeneration. By targeting KLF4 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications in diseases such as cancer and stem cell disorders.
With its high reactivity and specificity, the KLF4 Polyclonal Antibody is a valuable tool for investigators seeking to unravel the complexities of KLF4 biology and its impact on health and disease. Whether studying developmental pathways, cellular signaling, or disease mechanisms, this antibody provides reliable and accurate detection of KLF4 protein in a variety of experimental settings.
Product Name:
KLF4 Polyclonal Antibody
SKU:
CAB21709
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-479 of human KLF4 (NP_004226.3).
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
9314
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KLF4 Rabbit pAb (CAB21709) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
