The Kirrel3 Polyclonal Antibody (PACO10115) is a valuable tool for researchers studying Kirrel3, a cell adhesion molecule involved in synaptic function and neuronal development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry applications. By binding to the Kirrel3 protein, this antibody enables detection and analysis in various cell types, making it ideal for neuroscience and developmental biology research.Kirrel3, also known as nephrin-like protein 2, is essential for maintaining proper synaptic connections in the brain and is implicated in neurological disorders such as autism and schizophrenia.
Its role in synaptic plasticity and neuronal circuit formation makes it a promising target for investigating neurodevelopmental processes and understanding brain function. Researchers studying developmental disorders or neurological conditions can benefit from using this antibody to explore the function of Kirrel3 in normal and diseased states.
kin of IRRE like 3 (Drosophila);KIRREL3;KIAA1867;KIRRE;MGC126824;MGC126850;MRD4;NEPH2;PRO4502 ;
UniProt Protein Function:
KIRREL3: Could be involved in the hematopoietic supportive capacity of stroma cells. A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q24Cellular Component: axon; plasma membrane; extracellular region; integral to membrane; dendritic shaftMolecular Function: protein bindingBiological Process: pontine nucleus development; neuron migration; hemopoiesis; neurite morphogenesisDisease: Mental Retardation, Autosomal Dominant 4
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
