The KIR2DL3 Polyclonal Antibody (CAB1698) is specifically designed for research involving KIR2DL3, a type of killer cell immunoglobulin-like receptor (KIR) involved in immune response regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.KIR2DL3 is a cell surface receptor that plays a pivotal role in recognizing and interacting with HLA class I molecules, thereby influencing the function of natural killer (NK) cells and T cells in the immune response.
The KIR2DL3 Polyclonal Antibody binds specifically to the KIR2DL3 protein, allowing for the detection and analysis of this receptor in various cell types.Research involving KIR2DL3 is essential for understanding the mechanisms underlying immune response modulation and its implications in diseases such as cancer, autoimmune disorders, and infections. By elucidating the role of KIR2DL3 in immune regulation, researchers can develop targeted therapies aimed at modulating immune function for therapeutic purposes.
Product Name:
KIR2DL3 Rabbit Polyclonal Antibody
SKU:
CAB1698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-245 of human KIR2DL3 (NP_056952.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
38kDa
Observed MW:
45kDa
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Purification Method:
Affinity purification
Gene ID:
3804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KIR2DL3 antibody (CAB1698) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
