The KDM6B Rabbit Polyclonal Antibody (CAB12767) is a valuable tool for researchers studying KDM6B, a histone demethylase enzyme known for its role in epigenetic regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in various experimental techniques such as Western blotting.KDM6B, also known as JMJD3, is a key player in the regulation of gene expression through histone demethylation, particularly in processes like development, differentiation, and immune response.
Dysregulation of KDM6B has been implicated in various diseases, including cancer, neurological disorders, and inflammatory conditions. By targeting KDM6B with this antibody, researchers can gain insights into its function and potential therapeutic implications in these disease contexts.Overall, the CAB12767 antibody offers a reliable tool for investigating the role of KDM6B in epigenetic modulation, gene regulation, and disease pathogenesis, providing valuable information for advancing our understanding of these complex biological processes.
Product Name:
Kdm6b Polyclonal Antibody
SKU:
CAB12767
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of mouse Kdm6b (NP_001017426.1).
Enables beta-catenin binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including histone H3-K27 demethylation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; histone demethylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; gut; liver; metanephros; and olfactory epithelium. Orthologous to human KDM6B (lysine demethylase 6B).
Purification Method:
Affinity purification
Gene ID:
216850
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using Kdm6b Rabbit pAb antibody (CAB12767) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
