The KDM6A Monoclonal Antibody (PACO55826) is a powerful tool for researchers studying KDM6A, a key epigenetic regulator involved in gene expression and cellular differentiation. This antibody, produced using innovative technology, offers high specificity and sensitivity for detecting KDM6A in various experimental settings, including Western blotting and immunofluorescence.KDM6A, also known as JMJD3, is a histone demethylase that plays a crucial role in chromatin remodeling and gene transcription. Dysregulation of KDM6A has been linked to various diseases, including cancer, developmental disorders, and immune dysfunctions.
This antibody provides a reliable means to investigate the expression and function of KDM6A in these contexts, advancing our understanding of its biological roles and therapeutic potential.By targeting KDM6A, researchers can uncover novel insights into epigenetic mechanisms underlying disease pathogenesis and potentially identify new therapeutic targets for precision medicine approaches. The KDM6A Monoclonal Antibody (PACO55826) offers a valuable tool for such investigations, enabling precise and reliable detection of KDM6A protein levels in diverse biological samples.
Antibody Name:
KDM6A Antibody (PACO55826)
Antibody SKU:
PACO55826
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Lysine-specific demethylase 6A protein (620-749AA)
IHC image of PACO55826 diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Synonyms:
Lysine-specific demethylase 6A (EC 1.14.11) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein), KDM6A, UTX
UniProt Protein Function:
UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis. Protein type: Oxidoreductase; EC 1.14.11.-Chromosomal Location of Human Ortholog: Xp11.2Cellular Component: histone methyltransferase complex; nucleoplasm; nucleusMolecular Function: histone demethylase activityBiological Process: histone H3-K4 methylationDisease: Kabuki Syndrome 1; Kabuki Syndrome 2
UniProt Protein Details:
NCBI Summary:
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
