The IL-13 Polyclonal Antibody (AB10002) is a valuable tool for researchers studying the role of IL-13 in immune responses and inflammatory conditions. IL-13 is a cytokine that plays a key role in regulating immune cell function and promoting inflammation in various diseases, including asthma and autoimmune disorders. This antibody, generated in rabbits, is highly specific to human IL-13 and has been validated for use in Western blot applications. By binding to the IL-13 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential tool for immunology and cancer research studies.
Given IL-13's involvement in a wide range of diseases, understanding its activity and regulation is essential for developing targeted therapies. This antibody provides researchers with the ability to study the role of IL-13 in immune responses, making it a valuable asset for those investigating the mechanisms behind immune disorders and inflammatory conditions.
Product Name:
[KD Validated] IL13 Polyclonal Antibody
SKU:
CAB22112
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).
cytoplasm, external side of plasma membrane, extracellular region, extracellular space
Calculated MW:
16kDa
Observed MW:
13-16kDa
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Purification Method:
Affinity purification
Gene ID:
3596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and IL13 knockdown (KD) MCF7 cells, using [KD Validated] IL13 Rabbit pAb (CAB22112) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
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