The KCNU1 Polyclonal Antibody (CAB14967) is a research tool designed for studying KCNU1, a potassium channel protein that plays a key role in regulating neuronal excitability. This antibody, produced using a polyclonal approach, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the KCNU1 protein, allowing for accurate detection and analysis in various cell types, making it well-suited for investigations in neurobiology and epilepsy research.KCNU1, also known as the potassium calcium-activated channel subfamily U member 1, is crucial in controlling neuronal activity and synaptic transmission.
Its involvement in regulating potassium ion flow makes it a potential target for understanding and treating disorders like epilepsy and other neurological conditions. Studying the function of KCNU1 can provide insights into the mechanisms underlying these diseases, paving the way for the development of novel therapeutic interventions aimed at modulating potassium channels for therapeutic benefit.
Product Name:
KCNU1 Rabbit Polyclonal Antibody
SKU:
CAB14967
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2).
This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
157855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat testis, using KCNU1 Rabbit pAb (CAB14967) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
