KCNQ1 Rabbit Polyclonal Antibody (CAB2174)
- SKU:
- CAB2174
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | KCNQ1 Rabbit Polyclonal Antibody |
SKU: | CAB2174 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_861463.1). |
Sequence: | TAWR CYAA ENPD SSTW KIYI RKAP RSHT LLSP SPKP KKSV VVKK KKFK LDKD NGVT PGEK MLTV PHIT CDPP EERR LDHF SVDG YDSS VRKS PTLL EVSM PHFM RTNS FAED LDLE GETL LTPI THIS QLRE HHRA TIKV IRRM QYFV AKKK FQQA RKPY DVRD VIEQ YSQG HLNL MVRI KELQ RRLD QSIG KPSL FISV SEKS KDRG SNTI GARL NRVE DKVT QLDQ RLAL ITDM LHQL LSLH GGST PGSG GPPR EGGA HITQ PCGS GGSV DPEL FLPS NTLP TYEQ LTVP RRGP DEGS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; KCNQ1 |
Positive Sample: | 293T,Mouse pancreas,Rat lung,Rat kidney,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein. |
Calculated MW: | 75kDa |
Observed MW: | 70kDa/75kDa |
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3784 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |