The KCNQ1 Polyclonal Antibody (CAB2174) is a valuable tool for researchers studying KCNQ1, a potassium channel protein that plays a crucial role in cardiac function and regulation of the heart rhythm. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.KCNQ1 is essential for maintaining the electrical activity of the heart and mutations in this gene have been associated with various cardiac disorders, including Long QT syndrome. The KCNQ1 Polyclonal Antibody binds specifically to the KCNQ1 protein, allowing for accurate detection and analysis in a variety of cell types.
Research into KCNQ1 is important for understanding the molecular mechanisms underlying cardiac function and dysfunction. By studying the role of KCNQ1 in heart rhythm regulation, researchers can gain insights into potential therapeutic targets for cardiovascular diseases. The use of the KCNQ1 Polyclonal Antibody in immunology and cardiovascular research can help shed light on the pathophysiology of heart conditions and lead to the development of new treatment strategies.
Product Name:
KCNQ1 Rabbit Polyclonal Antibody
SKU:
CAB2174
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_861463.1).
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3784
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNQ1 Rabbit pAb (CAB2174) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
