The KCNN2 Polyclonal Antibody (PACO07185) is a valuable tool for researchers studying KCNN2, a potassium channel protein involved in various physiological processes, including the regulation of neuronal excitability and neurotransmitter release. This antibody, produced in rabbits, has been shown to exhibit high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the KCNN2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in neuroscience and neurobiology.
KCNN2, also known as intermediate conductance calcium-activated potassium channel protein 2, plays a crucial role in modulating neuronal activity through the regulation of potassium ion flow. Dysregulation of KCNN2 function has been implicated in several neurological disorders, making it an attractive target for research in areas such as epilepsy, Parkinson's disease, and cognitive disorders. Understanding the role of KCNN2 in neuronal signaling pathways is essential for the development of potential therapeutic interventions aimed at modulating neuronal excitability and neurotransmission.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Human BrainTissue using KCNN2(SK2) Rabbit pAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using KCNN2(SK2) Rabbit pAb diluted at 1:200.
Western blot analysis of 1) Rat BrainTissue, 2)Mouse Brain Tissue, 3) HepG2 with KCNN2(SK2) Rabbit pAb diluted at 1:2,000.
UniProt Protein Function:
KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5q22.3Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z discMolecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activityBiological Process: potassium ion transport
UniProt Protein Details:
NCBI Summary:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
