The KCNG3 Polyclonal Antibody (PACO07192) is a valuable tool for researchers studying the KCNG3 protein, a voltage-gated potassium channel subunit involved in regulating membrane potential and excitability in various cells, including neurons and cardiac myocytes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the KCNG3 protein, this antibody allows for the detection and analysis of KCNG3 expression in different cell types, making it ideal for investigations in neuroscience and cardiology.KCNG3, also known as Kv6.
3, plays a crucial role in controlling the electrical activity of cells by contributing to potassium ion flow across the cell membrane. Dysregulation of KCNG3 has been associated with neurological disorders, such as epilepsy and schizophrenia, as well as cardiac arrhythmias. Therefore, understanding the function of KCNG3 is essential for advancing research and developing targeted therapies for these conditions. With its high specificity and sensitivity, the KCNG3 Polyclonal Antibody is a valuable tool for exploring the physiological and pathological roles of KCNG3 in health and disease.
Antibody Name:
KCNG3 Antibody (PACO07192)
Antibody SKU:
PACO07192
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC-p:1:100-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using Kv10.1 Rabbit pAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using Kv10.1 Rabbit pAb diluted at 1:200.
Synonyms:
KCNG3; Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3
UniProt Protein Function:
KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 2p21Cellular Component: endoplasmic reticulum; plasma membrane; voltage-gated potassium channel complexMolecular Function: delayed rectifier potassium channel activity; protein binding
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
