Description
KCNA4 Antibody (CAB16390)
The KCNA4 Antibody (CAB16390) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.By targeting the KCNA4 protein, this antibody allows for the detection and analysis of this important ion channel in a variety of cell types. This makes it ideal for research in neurobiology, specifically in the areas of neuronal signaling and neurological disorders.The KCNA4 protein serves a crucial function in the nervous system by controlling the flow of potassium ions through cell membranes, thereby influencing neuronal firing and communication.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
| Product Name: | KCNA4 Antibody |
| SKU: | CAB16390 |
| Size: | 20μL, 100μL |
| Reactivity: | Mouse, Rat |
| Conjugate: | Unconjugated |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. | ||||
| Sequence: | DIFT EEVK FYQL GEEA LLKF REDE GFVR EEED RALP ENEF KKQI WLLF EYPE SSSP ARGI AIVS VLVI LISI VIFC LETL PEFR DDRD LVMA LSAG GHGG L | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | HK1, HBK4, PCN2, HPCN2, HUKII, KCNA8, KV1.4, KCNA4L, MCIDDS, KCNA4 |
| Positive Sample: | Rat brain |
| Cellular Localization: | Cell Membrane, Cell Projection, Multi-Pass Membrane Protein, Axon. |
| Calculated MW: | 73kDa |
| Observed MW: | 71kDa |
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.
| Purification Method | Affinity purification |
| Gene ID | 3739 |
| RRID | AB_2770043 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of lysates from Rat brain, using KCNA4 Rabbit pAb (CAB16390) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 20s. |
