The KCNA10 Polyclonal Antibody (CAB15681) is a valuable tool for researchers studying the KCNA10 protein, a voltage-gated potassium channel that plays a crucial role in the regulation of neuronal excitability. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.KCNA10 is known for its involvement in various neurological disorders, including epilepsy and neuropathic pain, making it a focus of interest in the field of neuroscience research. By targeting the KCNA10 protein, this antibody enables researchers to detect and analyze its expression in different cell types, providing insights into its function and potential therapeutic implications.
The KCNA10 Polyclonal Antibody is a valuable tool for studying the physiological and pathological roles of the KCNA10 channel in the nervous system, offering new avenues for exploring its involvement in neurological diseases and developing targeted therapies. Its high specificity and sensitivity make it a reliable choice for researchers looking to deepen their understanding of KCNA10 and its impact on neuronal function.
Product Name:
KCNA10 Rabbit Polyclonal Antibody
SKU:
CAB15681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human KCNA10 (NP_005540.1).
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
3744
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using KCNA10 Rabbit pAb (CAB15681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
