The KATNA1 Polyclonal Antibody (CAB16491) is a research tool designed for studying KATNA1, a protein involved in microtubule severing and cell division processes. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to KATNA1, this antibody enables researchers to detect and analyze the protein in various cell types, making it suitable for investigations in cell biology, cancer research, and neurology.KATNA1, also known as Katanin p60 ATPase-containing subunit A1, is essential for controlling microtubule dynamics and organization, thus playing a crucial role in cellular processes such as mitosis, cell migration, and intracellular transport.
Dysregulation of KATNA1 has been linked to various diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Understanding the function of KATNA1 is important for unraveling its role in these pathologies and identifying potential therapeutic targets.
Product Name:
KATNA1 Rabbit Polyclonal Antibody
SKU:
CAB16491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human KATNA1 (NP_001191005.1).
Cytoplasm, Midbody, centrosome, cytoskeleton, microtubule organizing center, spindle pole.
Calculated MW:
56kDa
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
11104
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat heart using KATNA1 Rabbit pAb (CAB16491) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
