IRF3 Antibody (PACO48970)
- SKU:
- PACO48970
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
IRF3 Antibody (PACO48970)
The IRF3 Polyclonal Antibody (PAC048970) is a valuable tool for researchers studying the immune system and antiviral responses. This antibody, raised in rabbits, is highly specific to human IRF3 protein and is validated for use in Western blot applications. By targeting the IRF3 protein, this antibody allows for the detection and analysis of IRF3 in various cell types, making it ideal for research in immunology and virology.IRF3, also known as interferon regulatory factor 3, plays a crucial role in the activation of antiviral genes and the production of type I interferons.
Understanding the function and regulation of IRF3 is essential for uncovering the mechanisms of antiviral immune responses and developing therapeutic strategies to combat viral infections. The IRF3 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of IRF3 in immune signaling pathways and host defense mechanisms.
| Antibody Name: | IRF3 Antibody (PACO48970) |
| Antibody SKU: | PACO48970 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human IRF3 protein (1-191AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: THP-1 whole cell lysate, A549 whole cell lysate. All lanes: IRF3 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO48970 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO48970 at dilution of 1:100. |
| Synonyms: | IRF3 protein (Interferon regulatory factor 3, isoform CRA_b), IRF3 |
| UniProt Protein Function: | IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 19q13.3-q13.4Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activityBiological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; negative regulation of defense response to virus by host; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of interferon-beta production; innate immune response; interferon type I biosynthetic process; response to DNA damage stimulus; defense response to virus; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of cytokine secretionDisease: Herpes Simplex Encephalitis, Susceptibility To, 7 |
| UniProt Protein Details: | |
| NCBI Summary: | IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
| UniProt Code: | Q96GL3 |
| NCBI GenInfo Identifier: | 1107689 |
| NCBI Gene ID: | 3661 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q96GL3,A8K7L2 |
| UniProt Related Accession: | Q96GL3,Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q71U93, Q7Z5G6, Q96GL3 |
| Molecular Weight: | 47,219 Da |
| NCBI Full Name: | interferon regulatory factor 3 |
| NCBI Synonym Full Names: | interferon regulatory factor 3 |
| NCBI Official Symbol: | IRF3Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | interferon regulatory factor 3; IRF-3 |
| UniProt Protein Name: | Interferon regulatory factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF3Â Â |
| UniProt Entry Name: | IRF3_HUMAN |
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