The IRF1 Polyclonal Antibody (CAB7692) is a valuable tool for researchers studying the immune regulatory protein IRF1. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to IRF1, researchers can effectively detect and analyze this important protein in various cell types.IRF1 is a key transcription factor involved in regulating immune responses, playing a crucial role in the activation of immune cells and the expression of genes involved in anti-viral and anti-tumor responses.
Understanding the function and regulation of IRF1 is essential for advancing research in immunology, cancer biology, and infectious diseases.Overall, the IRF1 Polyclonal Antibody is a reliable tool for investigating the role of IRF1 in immune regulation and disease pathology, making it an essential component for researchers in the fields of immunology and oncology.
Product Name:
IRF1 Rabbit Polyclonal Antibody
SKU:
CAB7692
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 181-280 of human IRF1 (NP_002189.1).
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer.
Purification Method:
Affinity purification
Gene ID:
3659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen, using IRF1 Rabbit pAb (CAB7692) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
