The INTS12 Antibody (PAC00971) is a valuable tool for researchers studying the INTS12 protein, which plays a critical role in the integrator complex and is involved in pre-mRNA processing. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding specifically to the INTS12 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in molecular biology and RNA processing research.The INTS12 protein is a key player in the integrator complex, which is involved in the regulation of gene expression through pre-mRNA processing.
Dysregulation of this complex has been implicated in various diseases, including cancer and developmental disorders. By understanding the function of INTS12 and its role in gene expression regulation, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic targets. The INTS12 Antibody (PAC00971) is a reliable tool for investigating the intricate mechanisms of the integrator complex and its implications in disease biology.
PHF22: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.Protein type: RNA-bindingChromosomal Location of Human Ortholog: 4q24Cellular Component: integrator complexMolecular Function: protein binding; zinc ion bindingBiological Process: snRNA processing
UniProt Protein Details:
NCBI Summary:
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
