Intermediate capsid protein VP6 Antibody (PACO34242)
The Intermediate Capsid Protein VP6 Antibody (PAC034242) is a valuable tool for researchers studying viral infections caused by the rotavirus, specifically targeting the VP6 protein. This antibody, produced in rabbits, exhibits high reactivity with samples from a variety of species and has been validated for use in a range of applications including Western blot and immunofluorescence.The VP6 protein is a key component of the rotavirus capsid structure, essential for viral replication and assembly. By targeting VP6, researchers can gain insights into the mechanisms of viral infection and potential strategies for antiviral interventions.
This antibody enables the detection and analysis of VP6 in different cell types, making it an invaluable resource for studies in virology and infectious diseases.Understanding the function of the VP6 protein is crucial for developing effective vaccines and therapeutics against rotavirus, a leading cause of severe diarrhea in infants and young children worldwide. By investigating the role of VP6 in viral pathogenesis, researchers can contribute to the development of interventions to prevent and treat rotavirus infections, ultimately improving global public health outcomes.
Antibody Name:
Intermediate capsid protein VP6 Antibody (PACO34242)
Antibody SKU:
PACO34242
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rotavirus A
Immunogen:
Recombinant Rotavirus A Intermediate capsid protein VP6 protein (1-397AA)
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
Synonyms:
Intermediate capsid protein VP6
UniProt Protein Function:
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
