Insulin Receptor Polyclonal Antibody (CAB21466)
- SKU:
- CAB21466
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | Insulin Receptor Polyclonal Antibody |
SKU: | CAB21466 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-570 of human Insulin Receptor (NP_000199.2). |
Sequence: | TKGR QERN DIAL KTNG DQAS CENE LLKF SYIR TSFD KILL RWEP YWPP DFRD LLGF MLFY KEAP YQNV TEFD GQDA CGSN SWTV VDID PPLR SNDP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HHF5; CD220; Insulin Receptor |
Positive Sample: | HCT116,Mouse liver,Rat liver,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 156kDa |
Observed MW: | 95kDa |
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |