IL15 Monoclonal Antibody (CAB23026)
- SKU:
- CAB23026
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | IL15 Monoclonal Antibody |
| SKU: | CAB23026 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1). |
| Sequence: | NWVN VISD LKKI EDLI QSMH IDAT LYTE SDVH PSCK VTAM KCFL LELQ VISL ESGD ASIH DTVE NLII LANN SLSS NGNV TESG CKEC EELE EKNI KEFL QSFV HIVQ MFIN TS |
| Tested Applications: | IHC-P ELISA |
| Recommended Dilution: | IHC-P,1:50 - 1:200 |
| Synonyms: | IL-15; IL15 |
| Conjugate: | Unconjugated |
| Cellular Localization: | cell surface, cytoplasm, cytosol, endosome, extracellular region, extracellular space, Golgi apparatus, nuclear speck, nucleoplasm |
| Calculated MW: | 18kDa |
| Observed MW: | Refer to figures |
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
| Purification Method: | Affinity purification |
| Gene ID: | 3600 |
| Clone Number: | ARC53689 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Immunohistochemistry analysis of paraffin-embedded human lung cancer using IL15 Rabbit mAb (CAB23026) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol |
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