The IL15 Monoclonal Antibody (ABM002) is a powerful tool for researchers studying IL15, a cytokine known for its role in regulating immune responses and inflammation. This antibody, produced in mice, is highly specific to IL15 and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.IL15 is a key player in the immune system, promoting the proliferation and activation of various immune cells, such as T cells and natural killer cells. Dysregulation of IL15 has been linked to a variety of conditions, including autoimmune diseases, infectious diseases, and cancer.
By targeting IL15 with this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.Whether investigating the immune response to infection, studying the role of IL15 in cancer progression, or exploring its potential as a therapeutic target, the IL15 Monoclonal Antibody is a valuable tool for advancing research in immunology and related fields. Trust in its specificity and reliability to support your experiments and drive groundbreaking discoveries.
Product Name:
IL15 Monoclonal Antibody
SKU:
CAB23026
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1).
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Purification Method:
Affinity purification
Gene ID:
3600
Clone Number:
ARC53689
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human lung cancer using IL15 Rabbit mAb (CAB23026) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol
