IL12RB2 Rabbit Polyclonal Antibody (CAB10348)
- SKU:
- CAB10348
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | IL12RB2 Rabbit Polyclonal Antibody |
SKU: | CAB10348 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1). |
Sequence: | GLLA PRQV SANS EGMD NILV TWQP PRKD PSAV QEYV VEWR ELHP GGDT QVPL NWLR SRPY NVSA LISE NIKS YICY EIRV YALS GDQG GCSS ILGN SKHK APLS GPHI NAIT EEKG SILI SWNS IPVQ EQMG CLLH YRIY WKER DSNS QPQL CEIP YRVS QNSH PINS LQPR VTYV LWMT ALTA AGES SHGN EREF CLQG K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | IL12RB2 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 97kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3595 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |