The IGFBP5 Polyclonal Antibody is essential for studies involving IGFBP5, a member of the insulin-like growth factor-binding protein family that plays a key role in regulating cell growth and survival. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blotting applications. It specifically targets the IGFBP5 protein, allowing for precise detection and analysis in a variety of cell types, making it a valuable tool for research in fields such as cancer and molecular biology.
IGFBP5 is known for its ability to interact with insulin-like growth factors, modulating their activity and influencing cellular processes such as proliferation and apoptosis. Dysregulation of IGFBP5 expression has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By studying the function of IGFBP5, researchers can gain valuable insights into the underlying mechanisms of disease progression and potentially identify new treatment strategies.
Product Name:
IGFBP5 Polyclonal Antibody
SKU:
CAB21745
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-272 of human IGFBP5 (NP_000590.1).
Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis.
Purification Method:
Affinity purification
Gene ID:
3488
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IGFBP5 antibody (CAB21745) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
