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GenieFluor 647 Anti-Human CD8a Antibody [OKT-8] (AGEL1394)

SKU:
AGEL1394
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
OKT-8
Conjugation:
AF 647
€139 - €469
Frequently bought together:

Description

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GenieFluor 647 Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (AF647 conjugated, OKT-8, Agel1394) is a cutting-edge tool for researchers investigating CD8a, a crucial cell surface protein involved in immune responses. This monoclonal antibody, conjugated with AF647 for fluorescent detection, offers high specificity and sensitivity in detecting CD8a in human samples. Validated for various applications such as flow cytometry and immunofluorescence, this antibody provides researchers with a reliable means to visualize and quantify CD8a expression in different cell types.CD8a, a co-receptor found on cytotoxic T cells, plays a pivotal role in immune surveillance and response to infections and tumors.

Its presence or absence on immune cells can provide insights into the functional status of the immune system and its ability to fight off pathogens or malignant cells. By targeting CD8a with this specific monoclonal antibody, researchers can better understand the distribution and dynamics of CD8a-expressing cells in immunological studies, cancer research, and autoimmune disease investigations.With its ability to accurately detect CD8a in human samples, the Human CD8a Monoclonal Antibody (AF647 conjugated, OKT-8, Agel1394) is an invaluable tool for unraveling the complex mechanisms of immune regulation and response in health and disease.

Product Title:GenieFluor 647 Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL1394
Size:20 Tests, 100 Tests, 200 Tests
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Genie Fluor 647 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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