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Biotin Anti-Human CD274/PD-L1 Antibody [29E.2A3] (AGEL1647)

SKU:
AGEL1647
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$167 - $383
Frequently bought together:

Description

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Biotin Anti-Human CD274/PD-L1 Antibody [29E.2A3]

The Human CD274 PD-L1 Monoclonal Antibody (Biotin Conjugated) 29E.2A3 (AGEL1647) offered by AssayGenie is a cutting-edge research tool specifically engineered for studying the PD-L1 protein, a key immune checkpoint regulator involved in immune response modulation. This monoclonal antibody, conjugated with biotin for enhanced detection capabilities, exhibits strong reactivity towards human samples, making it a reliable choice for a range of experimental applications.PD-L1, also known as Programmed Cell Death 1 Ligand 1, is a crucial molecule in regulating immune responses and maintaining immune tolerance. By binding to the PD-1 receptor on T cells, PD-L1 helps in suppressing excessive immune reactions, thus playing a vital role in preventing autoimmunity and maintaining immune balance. The study of PD-L1 has significant implications in various fields, particularly in immunology, oncology, and autoimmune disease research.

Utilizing the 29E.2A3 AGEL1647 antibody allows for precise detection and analysis of PD-L1 protein expression in different cell types, providing valuable insights into its role in immune regulation. This antibody's efficacy in Western blot applications further enhances its utility for researchers investigating the intricate mechanisms of immune checkpoint pathways and their dysregulation in various diseases.Overall, the Human CD274 PD-L1 Monoclonal Antibody (Biotin Conjugated) 29E.2A3 (AGEL1647) from AssayGenie serves as a sophisticated tool for advancing studies in immunology, cancer biology, and therapeutic development targeting immune checkpoint pathways. Its high specificity and reliability make it an indispensable asset for unraveling the complexities of PD-L1-mediated immune responses and exploring new avenues for treating immune-related disorders.

Product Title:Biotin Anti-Human CD274/PD-L1 Antibody [29E.2A3]
SKU:AGEL1647
Size:25µg, 100µg
Clone No:29E.2A3
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:Biotin Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q9NZQ7
Gene ID:29126
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

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