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APC Anti-Human CD274/PD-L1 Antibody [29E.2A3] (AGEL1650)

SKU:
AGEL1650
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$263 - $695
Frequently bought together:

Description

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APC Anti-Human CD274/PD-L1 Antibody [29E.2A3]

The Human CD274 (PD-L1) Monoclonal Antibody (APC Conjugated, 29E.2A3) is a cutting-edge tool for researchers delving into the role of the PD-L1 protein in immune regulation and cancer biology. This monoclonal antibody, conjugated with APC for enhanced detection capabilities, specifically targets human CD274 (PD-L1) and is validated for use in flow cytometry applications. By binding to PD-L1, this antibody enables precise detection and analysis of PD-L1 expression in diverse cell types, making it an invaluable resource for investigations in immunology and oncology.PD-L1, a checkpoint protein known for its role in immune evasion and suppression, is a critical molecule in the regulation of immune responses and the maintenance of immune tolerance. Its involvement in immune checkpoint pathways has positioned PD-L1 as a key target for research aimed at understanding and manipulating anti-tumor immune responses.

By elucidating the functions and interactions of PD-L1, researchers can gain insights into cancer immunotherapy and develop strategies to enhance immune responses against tumors while limiting autoimmune reactions.The Human CD274 (PD-L1) Monoclonal Antibody (APC Conjugated, 29E.2A3) serves as a powerful tool for investigating the complex interplay between PD-L1 expression and immune regulation in various disease contexts, particularly cancer. Its specificity, sensitivity, and reliable performance in flow cytometry make it an essential component of studies aiming to deepen our understanding of PD-L1 biology and explore innovative therapeutic approaches targeting the PD-1/PD-L1 axis. Unlock the potential of PD-L1 research with this advanced antibody and pave the way for novel insights into immune modulation and cancer immunity.

Product Title:APC Anti-Human CD274/PD-L1 Antibody [29E.2A3]
SKU:AGEL1650
Size:20 Tests, 100 Tests, 200 Tests
Clone No:29E.2A3
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:APC Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9NZQ7
Gene ID:29126
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

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