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APC Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1804)

SKU:
AGEL1804
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$263 - $923
Frequently bought together:

Description

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APC Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody (APC-conjugated) is a cutting-edge tool for researchers delving into the intricate world of immune cell migration and antigen presentation. This antibody, designated as G043H7-AGEL1804, specifically targets CCR7, a cell surface receptor known for its pivotal role in directing immune cells to lymphoid organs and facilitating immune responses.Manufactured using state-of-the-art technology, this monoclonal antibody offers high specificity and sensitivity in detecting human CCR7 in diverse sample types. Its APC conjugation allows for easy visualization and quantification of CCR7 expression in flow cytometry assays, aiding in comprehensive immune cell profiling and functional studies.CCR7, a key player in immune surveillance and adaptive immune responses, is crucial for the migration of dendritic cells and T cells to secondary lymphoid organs, where antigen presentation and T cell activation occur.

Understanding the dynamics of CCR7-mediated cell trafficking is essential in unraveling immune system functionality and developing immunotherapeutic strategies for various diseases, including cancer, infectious diseases, and autoimmune disorders.With its precise targeting of CCR7, the Human CD197 (CCR7) Monoclonal Antibody (APC-conjugated) stands as an indispensable tool for researchers seeking to explore the intricate mechanisms governing immune cell trafficking and activation in health and disease states.

Product Title:APC Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1804
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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