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Human AGER Polyclonal Antibody (CAB22536)

SKU:
CAB22536
$155
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Description

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Product Name:Human AGER Polyclonal Antibody
SKU:CAB22536
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-344 of human AGER(NP_001127.1).
Sequence:QNIT ARIG EPLV LKCK GAPK KPPQ RLEW KLNT GRTE AWKV LSPQ GGGP WDSV ARVL PNGS LFLP AVGI QDEG IFRC QAMN RNGK ETKS NYRV RVYQ IPGK PEIV DSAS ELTA GVPN KVGT CVSE GSYP AGTL SWHL DGKP LVPN EKGV SVKE QTRR HPET GLFT LQSE LMVT PARG GDPR PTFS CSFS PGLP RHRA LRTA PIQP RVWE PVPL EEVQ LVVE PEGG AVAP GGTV TLTC EVPA QPSP QIHW MKDG VPLP LPPS PVLI LPEI GPQD QGTY SCVA THSS HGPQ ESRA VSIS IIEP GEEG PTAG SVGG SGLG TLAL A
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:RAGE; sRAGE; SCARJ1; Human AGER
Positive Sample:Mouse lung,Rat lung
Conjugate:Unconjugated
Cellular Localization:apical plasma membrane, cell junction, extracellular region, fibrillar center, plasma membrane
Calculated MW:43kDa
Observed MW:45kDa/55kDa

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).

Purification Method:Affinity purification
Gene ID:177
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse lung using Human AGER Rabbit pAb(CAB22536) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time:0.1s.

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