Based on the information in the provided URL (https://www.assaygenie.com/hsd17b14-antibody-paco16494/), The HSD17B14 Polyclonal Antibody (PAC016494) is a valuable tool for research involving the HSD17B14 protein, which is known for its involvement in lipid metabolism and steroid hormone synthesis. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for various applications such as immunohistochemistry and ELISA.HSD17B14 is a key enzyme that plays a critical role in the biosynthesis of steroids, including sex hormones like estrogen and androgen. Dysregulation of HSD17B14 has been linked to various diseases, particularly hormone-related cancers such as breast and prostate cancer.
By targeting HSD17B14, researchers can explore potential therapeutic strategies for these malignancies and gain insights into the underlying mechanisms of hormone-driven tumorigenesis.Overall, the HSD17B14 Polyclonal Antibody is an essential tool for scientists conducting studies in the fields of endocrinology, oncology, and metabolism. Its ability to specifically detect HSD17B14 protein expression in human samples makes it a valuable asset in advancing our understanding of lipid metabolism and hormone-related diseases.
Antibody Name:
HSD17B14 Antibody (PACO16494)
Antibody SKU:
PACO16494
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human HSD17B14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16494(HSD17B14 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16494(HSD17B14 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acid, , prostaglandins, and xenobiotics. Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).
Synonyms:
hydroxysteroid (17-beta) dehydrogenase 14
UniProt Protein Function:
HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process
UniProt Protein Details:
NCBI Summary:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
