The HSBP1 Polyclonal Antibody (PACO09803) is a valuable tool for researchers studying the HSBP1 protein, which is involved in cellular stress response mechanisms. The antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the HSBP1 protein, this antibody enables detection and analysis in a variety of cell types, making it an ideal choice for investigations in cell biology and molecular biology research.HSBP1, a heat shock protein-binding protein, plays a crucial role in mediating cellular responses to stress conditions such as heat shock and oxidative stress.
Its involvement in maintaining cellular homeostasis and protecting against damage under stressful conditions highlights its importance in various physiological and pathological processes. Research into the function and regulation of HSBP1 is essential for understanding its potential implications in diseases related to stress response dysregulation, such as neurodegenerative disorders and cardiovascular diseases. Overall, the HSBP1 Polyclonal Antibody (PACO09803) offers a reliable and specific tool for investigating the role of HSBP1 in cellular stress responses and its potential as a therapeutic target in stress-related diseases.
heat shock factor binding protein 1;HSBP1;DKFZp686D1664;DKFZp686O24200;NPC-A-13 ;
UniProt Protein Function:
HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family.Chromosomal Location of Human Ortholog: 16q23.3Cellular Component: nucleoplasm; cytoskeleton; nucleusMolecular Function: transcription corepressor activityBiological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
