The HOXA13 Polyclonal Antibody (CAB9822) is a valuable tool for researchers studying the HOXA13 protein, a transcription factor involved in development and differentiation processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, allowing for precise detection in various experimental settings.HOXA13 is known to play a vital role in embryonic development, particularly in the formation of the limbs and genitalia. Dysregulation of HOXA13 has been linked to developmental abnormalities and diseases such as hand-foot-genital syndrome. Therefore, understanding the function and expression of HOXA13 is crucial for uncovering its potential roles in various physiological and pathological conditions.
The HOXA13 Polyclonal Antibody is validated for use in Western blot applications, enabling researchers to analyze the expression levels and localization of HOXA13 in different cell types and tissues. Its reliability and specificity make it an excellent tool for investigations in developmental biology, cell biology, and genetic disorders associated with the HOXA13 gene.Overall, the HOXA13 Polyclonal Antibody (CAB9822) offers researchers a valuable resource for studying the function and regulation of the HOXA13 protein in various biological processes, providing insights that could potentially lead to the development of novel therapeutic approaches for related disorders.
Product Name:
HOXA13 Rabbit Polyclonal Antibody
SKU:
CAB9822
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-320 of human HOXA13 (NP_000513.2).
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome.
Purification Method:
Affinity purification
Gene ID:
3209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HOXA13 antibody (CAB9822) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
