The HM13 Polyclonal Antibody (PACO09739) is a powerful tool for researchers studying HM13, a protein associated with immune regulation and immune responses. This antibody, produced in rabbits, boasts high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the HM13 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a valuable asset for studies in immunology and cancer research.HM13, also known as an immune regulatory protein, plays a crucial role in maintaining immune balance by modulating immune responses and inflammation.
Its involvement in immune system regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Deepening our understanding of HM13 activity is essential for developing novel therapies that aim to manipulate or enhance immune function in these disease contexts.
HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; EC 3.4.23.-; Membrane protein, multi-pass; Endoplasmic reticulum; ProteaseChromosomal Location of Human Ortholog: 20q11.21Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; lysosomal membrane; membrane; rough endoplasmic reticulumMolecular Function: aspartic endopeptidase activity, intramembrane cleaving; peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase bindingBiological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; protein homotetramerization; signal peptide processing
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
