UniProt Protein Function: | HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; EC 3.4.23.-; Membrane protein, multi-pass; Endoplasmic reticulum; ProteaseChromosomal Location of Human Ortholog: 20q11.21Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; lysosomal membrane; membrane; rough endoplasmic reticulumMolecular Function: aspartic endopeptidase activity, intramembrane cleaving; peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase bindingBiological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; protein homotetramerization; signal peptide processing |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TCT9 |
NCBI GenInfo Identifier: | 25008563 |
NCBI Gene ID: | 81502 |
NCBI Accession: | Q8TCT9.1 |
UniProt Secondary Accession: | Q8TCT9,Q15K36, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5 Q7Z4F2, Q86Y35, Q95H87 |
UniProt Related Accession: | Q8TCT9 |
Molecular Weight: | 36,814 Da |
NCBI Full Name: | Minor histocompatibility antigen H13 |
NCBI Synonym Full Names: | histocompatibility minor 13 |
NCBI Official Symbol: | HM13Â Â |
NCBI Official Synonym Symbols: | H13; SPP; IMP1; PSL3; IMPAS; SPPL1; PSENL3; IMPAS-1; MSTP086Â Â |
NCBI Protein Information: | minor histocompatibility antigen H13 |
UniProt Protein Name: | Minor histocompatibility antigen H13 |
UniProt Synonym Protein Names: | Intramembrane protease 1; IMP-1; IMPAS-1; hIMP1; Presenilin-like protein 3; Signal peptide peptidase |
Protein Family: | Minor histocompatibility antigen |
UniProt Gene Name: | HM13Â Â |
UniProt Entry Name: | HM13_HUMAN |