The Histone H1 Polyclonal Antibody (PACO00104) is a valuable tool for researchers studying histone H1, a key protein involved in chromatin compaction and gene regulation. This antibody, generated in rabbits, exhibits high specificity for human samples and is suitable for use in Western blot applications. By targeting the histone H1 protein, researchers can investigate its role in epigenetic regulation and its impact on gene expression in various cell types.Histone H1, often referred to as the linker histone, plays a crucial role in organizing and condensing chromatin structure, thereby influencing DNA accessibility and gene transcription.
Understanding the function of histone H1 is essential for unraveling the complexities of epigenetic regulation and its implications in diseases such as cancer and developmental disorders. The Histone H1 Polyclonal Antibody serves as a reliable tool for exploring these research areas and advancing our understanding of chromatin dynamics.
Antibody Name:
Histone H1 Antibody
Antibody SKU:
PACO00104
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB
Recommended Dilutions:
Species Reactivity:
Human, Mouse
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
