The HIST2H2L Monoclonal Antibody (PAC053114) is a vital tool for researchers studying histone proteins and their role in chromatin structure and gene expression regulation. This antibody, produced in mice, specifically targets the HIST2H2L protein and is optimized for use in various molecular biology techniques such as Western blot and immunofluorescence.Histone H2A type 2-Like (HIST2H2L) is a member of the histone H2A family and plays a crucial role in packaging DNA into chromatin, influencing gene transcription and DNA repair processes.
Dysregulation of histone proteins like HIST2H2L has been implicated in various diseases, including cancer and neurodegenerative disorders. By utilizing the HIST2H2L Monoclonal Antibody, researchers can further explore the function and regulation of histone proteins, advancing our understanding of epigenetic mechanisms and disease pathology.
Antibody Name:
hist2h2l Antibody (PACO53114)
Antibody SKU:
PACO53114
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Zebrafish
Immunogen:
Recombinant Zebrafish Histone H2B 3 protein (2-126AA)
Western Blot. Positive WB detected in: Zebrafish tissue 20μg, 10μg. All lanes: hist2h2l antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 14 kDa. Observed band size: 14 kDa.
Background:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms:
Histone H2B 3, hist2h2l
UniProt Protein Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
