The HINT1 Polyclonal Antibody (CAB10005) is a valuable tool for researchers studying the HINT1 protein, which plays a key role in various cellular processes including nucleotide metabolism and signal transduction. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the HINT1 protein, this antibody enables the detection and analysis of HINT1 in a wide range of cell types, making it essential for studies in biochemistry and molecular biology.
HINT1, also known as histidine triad nucleotide-binding protein 1, is a multifunctional enzyme involved in the maintenance of genomic stability and regulation of cellular responses to stress. Its dysregulation has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Investigating the function of HINT1 is crucial for understanding its role in these pathologies and developing potential therapeutic interventions.
Product Name:
HINT1 Polyclonal Antibody
SKU:
CAB21797
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human HINT1 (NP_005331.1).
This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed.
Purification Method:
Affinity purification
Gene ID:
3094
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HINT1 Rabbit pAb (CAB21797) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
