The HCN1 Polyclonal Antibody (CAB2969) is a valuable tool for researchers studying the HCN1 protein, which plays a key role in neuronal function and excitability. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the HCN1 protein, this antibody allows for the accurate detection and analysis of HCN1 expression in various cell types, making it ideal for research in neuroscience and neurology.HCN1 is a crucial component of hyperpolarization-activated cyclic nucleotide-gated channels, which control the excitability of neurons and play a role in regulating synaptic transmission.
Dysregulation of HCN1 has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and neuropathic pain. Studying the expression and function of HCN1 using this antibody can provide valuable insights into the underlying mechanisms of these disorders, potentially leading to the development of novel therapeutic strategies targeting HCN1.
Product Name:
HCN1 Rabbit Polyclonal Antibody
SKU:
CAB2969
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HCN1 (O60741).
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
Purification Method:
Affinity purification
Gene ID:
348980
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HCN1 Rabbit pAb (CAB2969) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
