The HAUS7 Antibody (PAC020812) is a polyclonal antibody specifically designed for research involving the HAUS7 protein. HAUS7 is a critical component of the augmin complex, responsible for microtubule nucleation during mitosis. This antibody, generated in rabbits, shows high reactivity towards human samples and is validated for use in various applications including Western blotting.By targeting the HAUS7 protein, this antibody enables researchers to study and analyze its function in different cell types, providing valuable insights into cell division processes.
The HAUS7 protein's role in microtubule nucleation makes it a key player in cell division and could have implications in cancer research and therapeutic development.Understanding the function of HAUS7 and its involvement in mitosis is essential for advancing our knowledge of cell biology and exploring potential therapeutic strategies targeting cell division processes. The HAUS7 Antibody (PAC020812) offers a valuable tool for researchers looking to elucidate the mechanisms underlying cell division and its implications in various disease states.
Antibody Name:
HAUS7 Antibody (PACO20812)
Antibody SKU:
PACO20812
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HAUS7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20812(HAUS7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
Synonyms:
HAUS augmin-like complex, subunit 7
UniProt Protein Function:
HAUS7: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Belongs to the HAUS7 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Deoxyribonuclease; DNA-binding; EC 3.1.11.2Chromosomal Location of Human Ortholog: Xq28Cellular Component: centrosome; cytoplasm; cytosol; nucleolus; plasma membraneMolecular Function: thioesterase bindingBiological Process: centrosome organization and biogenesis; G2/M transition of mitotic cell cycle; spindle assembly
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
