The Haptoglobin Polyclonal Antibody (CAB1571) is a powerful tool for researchers studying haptoglobin, a key protein involved in the immune response and inflammation. This antibody, produced in rabbits, has been extensively validated for use in Western blot applications and is highly reactive with human samples.Haptoglobin is an important marker of inflammation and is implicated in various diseases such as cancer, cardiovascular disease, and autoimmune disorders. By using this antibody, researchers can detect and analyze haptoglobin in a variety of cell types, shedding light on its role in immune regulation and disease progression.
With its high specificity and sensitivity, the Haptoglobin Polyclonal Antibody is an essential tool for studies in immunology, oncology, and inflammatory diseases. By targeting haptoglobin, researchers can further our understanding of immune responses and potentially uncover new therapeutic targets for a range of conditions.
Product Name:
Haptoglobin (HP) Rabbit Polyclonal Antibody
SKU:
CAB1571
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Haptoglobin (Haptoglobin (HP)) (NP_005134.1).
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Haptoglobin (HP) Rabbit pAb (CAB1571) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
