The GypB Polyclonal Antibody (CAB15063) is a valuable tool for researchers studying GypB, a protein involved in regulating red blood cell membrane stability and function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By targeting the GypB protein, this antibody enables precise detection and analysis in different cell types, making it an essential resource for investigations in hematology and blood disorders.
GypB, also known as glycophorin B, plays a critical role in maintaining the integrity of red blood cells and ensuring proper oxygen transport throughout the body. Mutations or dysregulation of GypB have been linked to various blood disorders, such as hereditary spherocytosis and elliptocytosis. Understanding the function of GypB is essential for developing a deeper insight into these conditions and exploring potential therapeutic interventions aimed at restoring red blood cell health.
Product Name:
GYPB Rabbit Polyclonal Antibody
SKU:
CAB15063
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-91 of human GYPB (NP_002091.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
10kDa
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2994
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using GYPB antibody (CAB15063) at dilution of 1:100. Blue: DAPI for nuclear staining.
