The GTF2I Polyclonal Antibody (CAB12441) is a valuable tool for researchers studying the GTF2I protein, which is involved in transcriptional regulation and plays a key role in various cellular processes. This antibody, produced in rabbits, shows high specificity for human samples and is validated for use in techniques such as Western blotting.GTF2I is a transcription factor that modulates gene expression, impacting cell growth, differentiation, and development. Dysregulation of GTF2I has been linked to various diseases, making it an important target for research in fields such as cancer biology and developmental biology.
By detecting and studying the GTF2I protein, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify therapeutic targets. Overall, the GTF2I Polyclonal Antibody is a reliable tool for investigating the function of the GTF2I protein in different cellular contexts and disease models, ultimately contributing to our understanding of gene regulation and potential therapeutic interventions.
Product Name:
GTF2I Rabbit Polyclonal Antibody
SKU:
CAB12441
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-810 of human GTF2I (NP_001157108.1).
This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
2969
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GTF2I antibody (CAB12441) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
