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GSTT1 Monoclonal Antibody [PAT38D11AT] (CPAB0207)

SKU:
CPAB0207
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT38D11AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

GSTT1 Monoclonal Antibody [PAT38D11AT] (CPAB0207)

The GSTT1 Polyclonal Antibody (CPAB0207) is a key tool for research involving Glutathione S-transferase theta 1 (GSTT1), an enzyme involved in cellular detoxification processes. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding specifically to GSTT1, this antibody enables the accurate detection and analysis of this important enzyme in a variety of cell types.GSTT1 is known for its role in detoxifying harmful compounds, particularly those derived from environmental toxins and medications. Research into GSTT1 is essential for understanding how cells defend themselves against damage and maintain overall health.

Additionally, genetic variations in GSTT1 have been associated with an increased risk of certain diseases, making it a promising target for investigations into conditions such as cancer, neurodegenerative disorders, and drug toxicity.By using the GSTT1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of this crucial enzyme, ultimately paving the way for potential therapeutic interventions and personalized medicine approaches.

Product Name:GSTT1 Antibody
Product Sku:CPAB0207
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GSTT1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GSTT1 amino acids 1-24 purified from Ecoli.
Clone:PAT38D11AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:GSTT1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b
Background:GSTT1 belongs to a superfamily of proteins which catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. GSTT1 is one of the GSTs€™ four main classes: alpha, mu, pi and theta (which includes GSTT1 and GSTT2). GSTT1 is involved in activation and detoxification reactions and catalyzes the conjugation of industrial chemicals, such as epoxybutane, ethylene oxides, halomethane with glutathione. GSTT1 is found in erythrocytes, at low levels in the liver as well as in Clara and ciliated cells at the alveolar/bronchiolar junction in the lung. The GSTT1 gene is deficient in 38% of the population. The GSTTI enzyme deficiency might influence the individual risk for development of acquired aplastic anemia and acute myeloid leukemia. The presence or absence of the GSTT1 gene is concurrent with GSST1+ (the conjugator) and GSTT1- (the non-conjugator) phenotypes correspondingly. The GSTT1+ phenotype is able to catalyze the glutathione conjugation of dichloromethane. GSTT1-null genotypes are seen as having a higher risk of developing leukoplakia. Germline genetic polymorphism in GSTT1 is linked to breast cancer.
Synonyms:Glutathione S-transferase theta-1, GST class-theta-1, Glutathione transferase T1-1, GSTT1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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