Based on the information provided in the URL for the GSTM4 Polyclonal Antibody (CAB7434), we can create a product description as follows:The GSTM4 Polyclonal Antibody (CAB7434) is a valuable tool for researchers studying the GSTM4 protein, an important member of the glutathione S-transferase (GST) family involved in detoxification processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the GSTM4 protein, this antibody enables precise detection and analysis in various experimental settings.GSTM4, a crucial enzyme in cellular defense mechanisms against toxic compounds and oxidative stress, plays a significant role in regulating intracellular processes related to metabolism and protection from environmental insults.
Its diverse functions make it a key target for investigations into drug metabolism, antioxidant response, and oxidative damage in various tissues and disease states. Researchers in fields such as pharmacology, toxicology, and oncology can benefit from using this antibody to dissect the roles of GSTM4 in health and disease.Overall, the GSTM4 Polyclonal Antibody (CAB7434) provides reliable and specific detection of the GSTM4 protein, offering researchers a valuable tool for exploring its functional significance in cellular processes and disease pathways. Its applications extend to a wide range of research areas, including drug development, environmental toxicology, and cancer biology, making it an essential component of
Product Name:
GSTM4 Rabbit Polyclonal Antibody
SKU:
CAB7434
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human GSTM4 (NP_000841.1).
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Purification Method:
Affinity purification
Gene ID:
2948
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GSTM4 antibody (CAB7434) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
