The GRPR Polyclonal Antibody (CAB2940) is a valuable tool for researchers studying the Gastrin-releasing peptide receptor (GRPR), a protein that is involved in various physiological processes including pain transmission, cancer cell growth, and neuroendocrine regulation. This antibody is produced in rabbits and has been shown to have high reactivity with human samples, making it suitable for use in Western blotting applications.By specifically binding to the GRPR protein, this antibody enables researchers to accurately detect and analyze GRPR expression in different cell types, providing valuable insights for studies in neuroscience, oncology, and endocrinology.
The role of GRPR in regulating cellular processes and disease states makes it a promising target for the development of novel therapeutic interventions in cancer, chronic pain, and neurological disorders.Overall, the GRPR Polyclonal Antibody is a reliable reagent for investigating the function and expression of GRPR in various research contexts, paving the way for potential advancements in understanding and treating diseases related to this important signaling receptor.
Product Name:
GRPR Rabbit Polyclonal Antibody
SKU:
CAB2940
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1).
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Purification Method:
Affinity purification
Gene ID:
2925
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRPR Rabbit pAb (CAB2940) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
