The GPR39 Polyclonal Antibody (PACO54798) is a valuable tool for researchers investigating GPR39, a G protein-coupled receptor involved in various physiological processes, including metabolism and gastrointestinal function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.GPR39, also known as the zinc receptor, has been implicated in regulating appetite and glucose metabolism, making it a potential target for treating metabolic disorders such as obesity and diabetes. Additionally, GPR39 has been linked to gastrointestinal diseases and inflammatory conditions, highlighting its importance in understanding and potentially treating these disorders.
By binding to the GPR39 protein, this antibody enables researchers to detect and analyze GPR39 expression in different cell types, providing valuable insights into its role in health and disease. With its versatility and reliability, the GPR39 Polyclonal Antibody is an essential tool for advancing research in metabolism, gastrointestinal health, and inflammatory disorders.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO54798 at dilution of 1:100.
Immunofluorescence staining of HepG2 cells with PACO54798 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-α and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
Synonyms:
G-protein coupled receptor 39, GPR39
UniProt Protein Function:
GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralChromosomal Location of Human Ortholog: 2q21-q22Cellular Component: integral to plasma membrane; plasma membrane
UniProt Protein Details:
NCBI Summary:
This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
