The GPM6B Polyclonal Antibody (PACO35366) is a crucial tool for research involving GPM6B, a glycoprotein known to play a role in neuronal development and synaptic plasticity. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GPM6B protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in neuroscience and neurobiology.GPM6B is a key player in neuronal function, being involved in processes such as neurite outgrowth and synaptic transmission.
Its importance in maintaining proper brain function makes it a valuable target for research into neurological disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Investigating the function of GPM6B can provide insights into the underlying mechanisms of these conditions, potentially leading to the development of novel therapeutic strategies aimed at treating or preventing them.
Western blot. All lanes: GPM6B antibody at 5µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29, 27, 34, 37 kDa. Observed band size: 29 kDa.
Immunofluorescent analysis of HepG2 cells using PACO35366 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO35366 at dilution of 1:100.
Background:
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
GPM6B: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Belongs to the myelin proteolipid protein family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: Xp22.2Cellular Component: lipid raft; plasma membraneBiological Process: negative regulation of serotonin uptake; positive regulation of bone mineralization; regulation of actin cytoskeleton organization and biogenesis; regulation of focal adhesion formation
UniProt Protein Details:
NCBI Summary:
This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]
