The GMPPA Polyclonal Antibody (PACO09503) is a powerful tool for researchers studying GMPPA, an enzyme involved in nucleotide sugar biosynthesis and protein glycosylation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting GMPPA in human samples, making it a valuable asset for Western blot applications.GMPPA, also known as GDP-mannose pyrophosphorylase A, plays a vital role in the biosynthesis of sugar nucleotides, which are essential for the glycosylation of proteins. Dysregulation of GMPPA has been associated with various diseases, including cancer, diabetes, and congenital disorders.
By targeting GMPPA with this antibody, researchers can gain insights into the role of this enzyme in normal physiology and disease pathogenesis.The GMPPA Polyclonal Antibody is a reliable tool for investigating the function and expression of GMPPA in different cell types and tissues. Its versatility and high sensitivity make it ideal for studies in glycobiology, biochemistry, and molecular biology, ultimately leading to a better understanding of GMPPA-related diseases and the development of potential therapeutic interventions.
GMPPA: This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]Protein type: Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; EC 2.7.7.13Chromosomal Location of Human Ortholog: 2q35Cellular Component: cytoplasmMolecular Function: nucleotidyltransferase activityBiological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; GDP-mannose biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modificationDisease: Alacrima, Achalasia, And Mental Retardation Syndrome
UniProt Protein Details:
NCBI Summary:
This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
