The GIMAP2 Polyclonal Antibody (PAC023438) is a valuable tool for researchers studying GIMAP2 protein, a member of the GTPase family involved in immune cell function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By specifically binding to the GIMAP2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.
GIMAP2 is known for its role in regulating immune cell survival and function, particularly in T cells. Its involvement in immune cell homeostasis and signaling pathways makes it a key target for studying immune responses in diseases like cancer, autoimmune conditions, and inflammatory disorders. Research into GIMAP2 can provide valuable insights into immune modulation and the development of targeted therapies for immune-related diseases.
Synthesized peptide derived from internal of human GIMAP2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using GIMAP2 antibody.
Immunofluorescence analysis of A549 cells, using GIMAP2 antibody.
Background:
The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.
Synonyms:
gima2; gimap2; gtpase imap family member 2; gtpase; imap family member 2
UniProt Protein Function:
GIMAP2: a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integral; Hydrolase; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytoplasm; integral to membrane; lipid particleMolecular Function: GTP binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
