The GHR Polyclonal Antibody (CAB14735) is a versatile tool for researchers studying the growth hormone receptor (GHR) pathway. This antibody, produced in rabbits, has high reactivity with human samples, making it ideal for use in Western blot applications. By specifically binding to the GHR protein, this antibody enables accurate detection and analysis in a variety of cell types.The growth hormone receptor is a key player in the regulation of growth and metabolism, making it a crucial target for studies in endocrinology, developmental biology, and cancer research. Dysregulation of the GHR pathway has been implicated in various diseases, including growth disorders and certain types of cancer.
By studying the activity of GHR using this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the GHR Polyclonal Antibody (CAB14735) is a valuable tool for investigating the role of the growth hormone receptor in health and disease. Its high reactivity and specificity make it a reliable choice for researchers looking to deepen their understanding of the GHR pathway and its implications for human health.
Product Name:
GHR Rabbit Polyclonal Antibody
SKU:
CAB14735
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-260 of human GHR (NP_001229328.1).
Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein.
Calculated MW:
72kDa
Observed MW:
72kDa
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2690
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GHR Rabbit pAb (CAB14735) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
