UniProt Protein Function: | Function: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.1 PublicationManual assertion based on experiment in:Ref.1Catalytic activity: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.Cofactor: FAD.1 PublicationManual assertion based on experiment in:Ref.3 |
UniProt Protein Details: | |
NCBI Summary: | protein that augments liver regeneration [RGD, Feb 2006] |
UniProt Code: | Q63042 |
NCBI GenInfo Identifier: | 347800639 |
NCBI Gene ID: | 27100 |
NCBI Accession: | NP_037354.2 |
UniProt Secondary Accession: | Q63042 |
UniProt Related Accession: | Q63042 |
Molecular Weight: | 22,837 Da |
NCBI Full Name: | FAD-linked sulfhydryl oxidase ALR |
NCBI Synonym Full Names: | growth factor, augmenter of liver regeneration |
NCBI Official Symbol: | Gfer  |
NCBI Official Synonym Symbols: | ALRÂ Â |
NCBI Protein Information: | FAD-linked sulfhydryl oxidase ALR; growth factor, erv1 homolog; augmenter of liver regeneration; growth factor, erv1-like (augmenter of liver regeneration) |
UniProt Protein Name: | FAD-linked sulfhydryl oxidase ALR |
UniProt Synonym Protein Names: | Augmenter of liver regeneration |
Protein Family: | FAD-linked sulfhydryl oxidase |
UniProt Gene Name: | Gfer  |
UniProt Entry Name: | ALR_RAT |